Pb212(ThB) Tracer Studies in Adult Beagle Dogs.

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Abstract
Beagle metabolism of shortlived carrier free Pb212 was studied following intravenous injection, and after transfusion of blood cells tagged with Pb212 in vitro. The latter proved to be a satisfactory method to determine blood volume. When Pb212 was given intravenously, in vivo tagging of blood cells occurred. A maximum of 65% of the activity in cells was reached at 2 to 3 hours after injection, then Pb212 in blood cells decreased with a biological t1/2 = 37 hours and an effective t1/2 = 8.2 hours. The same decrease occurred after injection of in vitro tagged cells. In both experiments essentially all Pb212 decayed inside the dog. Half decayed in blood in the vivo tagging experiment; 4/5 decayed in blood when tagging was done in vitro.