Methods for the detection and quantitation of angiotensin converting enzyme inhibitors in fermentation broths.
- 1 January 1985
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 38 (8) , 993-996
- https://doi.org/10.7164/antibiotics.38.993
Abstract
Two procedures are described for the detection of inhibitors of angiotensin converting enzyme (ACE). The first is a new agar-plate method useful as a screening tool. Two ACE inhibitors produced by culture A58365 were discovered using this plate test. The second method is a modification of a previously reported spectrophotometric procedure. Both procedures utilize p-nitrobenzyl-oxycarbonylglycyl-(S-4-nitrobenzo-2-oxa-1,3-diazole)-L-cysteinylglycine as substrate.This publication has 4 references indexed in Scilit:
- Angiotensin converting enzyme inhibitors produced by Streptomyces chromofuscus. Discovery, taxonomy and fermentation.The Journal of Antibiotics, 1985
- A new chromogenic substrate for angiotensin-converting enzymeAnalytical Biochemistry, 1978
- Design of Specific Inhibitors of Angiotensin-Converting Enzyme: New Class of Orally Active Antihypertensive AgentsScience, 1977
- Kinetic properties of pulmonary angiotensin-converting enzyme. Hydrolysis of hippurylglycylglycineBiochimica et Biophysica Acta (BBA) - Enzymology, 1976