The Superiority of Small Charcoal Particles (Filmadsorber) in the Removal of Protein‐Bound Cholephilic Anions

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Abstract
A hemoperfusion system has been developed in which very small charcoal particles (mean diameter: 40 μm) are embedded in a collodion film (Filmadsorber). In vitro adsorption studies have revealed that the adsorption of bile acids by these small charcoal particles is superior to that by larger ones (diameter: 0.5 to 5 mm) as used in commercially available charcoal adsorbers (Becton‐Diek‐inson, Gambro, and Haemocol), and to that by neutral XAD resins. Dogs with ligated bile ducts were subjected to hemoperfusion through the four different types of ch arcoal adsorbers and an XAD filmadsorber, confirming the in vitro resu!ts that small charcoal particles, as used in the Filmadsorber, are superior to larger ones and to XAD resins with respect to the removal of protein‐bound cholephilic anions (bile acids, bilirubin) from the blood stream.

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