The Complement System of Man

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Abstract
Phylogeny, Ontogeny and BiologyPhylogenyThe nine components of the classic hemolytic complement system and certain proteins of the alternate pathway have been recognized in terms of both physicochemical and functional characteristics in man.4 In lower species the knowledge of the complement system is less complete,34, 59 but functional data concerning the classic and alternate pathways are sufficient to permit a preliminary analysis of the phylogenetic development of this system.60 Invertebrates. Studies of complement available in invertebrate species include representatives of the arthropoda (horseshoe crab), sipunculoidea (sipunculid worm), and echinodermata (starfish). No lytic activity has been demonstrated in the hemolymph of . . .