SERUM AND AQUEOUS HUMOUR CONCENTRATION OF TRANEXAMIC ACID AFTER PERORAL ADMINISTRATION

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Abstract
After a single oral dose of 25 mg/kg tranexamic acid in 37 patients with cataract as the sole eye disease, the concentration of the drug was measured in the serum and the aqueous at various intervals after intake. The serum concentration was highest after 3 h (average 15.44 mg/l), but a trace of tranexamic acid (0.7 mg/l) could still be found after 19 h. In the aqueous, the concentration was highest after 3 h (average 1.62 mg/l), but, after this, the fall in tranexamic acid concentration was very gradual and after 19 h was 1.3 mg/l. In 2 patients who had received 25 mg/kg 3 times daily for 3 days, an aqueous concentration of 2.3 mg/l was found 8 h after the final intake. [In ophthalmology, tranexamic acid was used in the treatment of hyphema and in the prevention of secondary hemorrhages after cataract surgery.].