Effects of Repeated Administrations of Facteur Thymique Sérique (FTS) on Biochemical Changes Related to Aging in Senescence-Accelerated Mouse (SAM)

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Abstract
Superoxide dismutase (SOD) activity, malondialdehyde (MDA) content and monoamine oxidase B (MAO-B) activity were measured in the brain, liver and kidney of a normal aging strain (R/1) and an accelerating aging strain (P/8) senescence-accelerated mice (SAM) at 9-10 months of age, and the effects of facteur thymique serique (FTS) were examined. The activity of Cu, Zn-SOD in the kidney and MAO-B in the liver was significantly low and high in SAM-P/8 compared to SAM-R/1. FTS enhanced the activity of Mn-SOD and Cu, Zn-SOD in the kidney of SAM-P/8 and Cu, Zn-Sod activity in the brain of both SAM-P/8 and SAM-R/1. It decreased the activity of MAO-B in the liver and the contents of malondialdehyde (MDA) in the brain and kidney of SAM-P/8. Thus, FTS affects the biochemical factors related to senescence in SAM-P/8, a particular senescent animal model, and may thus possibly be effective as an anti-senescent medicine.