PLATELET-AGGREGATION INHIBITION IN HUMAN UMBILICAL VEIN GRAFTS AND NEGATIVELY CHARGED BOVINE HETEROGRAFTS
- 1 January 1979
- journal article
- research article
- Vol. 85 (4) , 395-399
Abstract
Glutaraldehyde-tanned human umbilical vein grafts (4 mm) and negatively charged bovine heterografts (4 mm) were placed as bypasses in the femoral arteries of 20 dogs randomized into 10 treated with aspirin and dipyridamole and 10 were not treated. Autogenous vein grafts were placed as controls. Platelet aggregation inhibition by aspirin and dipyridamole significantly improved the patency of human umbilical vein grafts from 10%-60%. It had no effect on patencies of autogenous veins (100%) or on negatively charged bovine heterografts (0% patency). Inherent graft properties continue to play an important and sometimes overriding role in long-term graft patency in small vessel bypasses. Neointimal fibrous hyperplasia at both proximal and distal anastomoses again was intimately associated with late graft occlusions.This publication has 4 references indexed in Scilit:
- Human Umbilical Veins and Autogenous Veins as Canine Arterial Bypass GraftsAnnals of Surgery, 1978
- PREVENTION OF PLATELET-AGGREGATION AND ADHERENCE TO PROSTHETIC VASCULAR GRAFTS BY ASPIRIN AND DIPYRIDAMOLE1978
- AUTOGENOUS VENOUS GRAFTS 10 YEARS LATER1977
- CLINICAL EXPERIENCE WITH MODIFIED HUMAN UMBILICAL-CORD VEIN FOR ARTERIAL BYPASS1976