Synaptophysin expression in the striatum in Huntington's disease
- 1 May 1990
- journal article
- research article
- Published by Springer Nature in Acta Neuropathologica
- Vol. 80 (1) , 88-91
- https://doi.org/10.1007/bf00294227
Abstract
This immunohistochemical study compares the expression of synaptophysin (SYP) in the striatum in Huntington's disease (HD) with that of calcineurin (CaN), a marker for striatal medium-sized spinous neurons. As compared to controls, in the HD striatum there was a significant loss of SYP immunoreactivity with residual staining displaying an inhomogeneous pattern, which strikingly resembled that of CaN. Our results may indicate that there is a synaptic loss in the striatum with HD and this is most likely due to loss of medium-sized spinous neurons characteristic of this disease.Keywords
This publication has 15 references indexed in Scilit:
- Subdivisional involvement of nigrostriatal loop in idiopathic parkinson's disease and striatonigral degenerationAnnals of Neurology, 1989
- A COMPARATIVE IMMUNOCYTOCHEMICAL STUDY OF HUMAN CEREBELLAR CORTEX IN X–CHROMOSOME–LINKED COPPER MALABSORPTION (MENKES‘ KINKY HAIR DISEASE) AND GRANULE CELL TYPE CEREBELLAR DEGENERATIONNeuropathology and Applied Neurobiology, 1989
- An immunohistochemical investigation of the human neostriatum in huntington's diseaseAnnals of Neurology, 1989
- LOSS OF MATRIX CALCIUM-BINDING PROTEIN-CONTAINING NEURONS IN HUNTINGTON'S DISEASEThe Lancet, 1988
- Protein p38: an integral membrane protein specific for small vesicles of neurons and neuroendocrine cells.The Journal of cell biology, 1986
- Selective Sparing of a Class of Striatal Neurons in Huntington's DiseaseScience, 1985
- Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesiclesCell, 1985
- Evidence for Degenerative and Regenerative Changes in Neostriatal Spiny Neurons in Huntington's DiseaseScience, 1985
- Synapses of Identified Neurons in the NeostriatumPublished by Wiley ,1984
- Ramifications of the globus pallidus in the rat as indicated by patterns of immunohistochemistryNeuroscience, 1983