ALTERATIONS IN ADRENAL GROWTH AND CORTICOSTEROID CONTENT IN FOETAL AND NEONATAL RATS DEVELOPING AT HIGH ALTITUDE
- 1 March 1979
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 80 (3) , 333-342
- https://doi.org/10.1677/joe.0.0800333
Abstract
To study the effects of chronic maternal hypoxia on the growth and functional development of foetal and neonatal adrenal glands, Long–Evans rats were acclimatized to high altitude (3800 m) before mating and were maintained at this height throughout gestation. The body growth of the progeny at high altitude was essentially normal during the perinatal period, but adrenal weight and adrenocortical function showed marked differences from those of control rats maintained at sea level. The adrenal glands were larger in foetuses but smaller in neonates, compared with the adrenal glands of control animals maintained at sea level. Differences in the protein content of the adrenal glands between the two groups paralleled differences in adrenal weight. The concentration and content of corticosterone in the adrenal glands of both foetuses and neonates kept at high altitude were markedly lower than values in animals kept at sea level. The lower adrenal corticosterone content was not reflected in the concentration of the hormone in the peripheral plasma, since this was essentially the same at high altitude and at sea level in both mothers and perinatal animals. The reduction in the adrenal corticosterone content was accompanied by and may have resulted from, a reduction in the concentration of cytochrome P-450 in the adrenal tissue of foetuses maintained at high altitude. Possible explanations for the dichotomous results are discussed.This publication has 16 references indexed in Scilit:
- Response of the Adrenal Cortex of the Neonatal Rat after Subjection to StressNature, 1966
- Response of the Infantile Rat to StressEndocrinology, 1966
- Response of the Hypothalamic-Hypophyseal Adrenal Axis to Stress: Observations in Fetal and Caesarean Newborn Rats.Experimental Biology and Medicine, 1965
- The Carbon Monoxide-binding Pigment of Liver MicrosomesJournal of Biological Chemistry, 1964
- The Carbon Monoxide-binding Pigment of Liver MicrosomesJournal of Biological Chemistry, 1964
- Fluorometric Determination of Corticosterone and Cortisol in 0.02–0.05 Milliliters of Plasma or Submilligram Samples of Adrenal Tissue1Endocrinology, 1964
- Studies of the Pituitary-Adrenocortical System in the Fetal RatEndocrinology, 1962
- FETAL-MATERNAL ENDOCRINE INTERRELATIONS: THE HYPOPHYSEAL-ADRENAL SYSTEM1Endocrinology, 1955
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951
- THE MATURATION OF THE PITUITARY-ADRENAL AXIS IN THE NEWBORN RAT1Endocrinology, 1950