The inhibitory effect of intraventricular administration of serotonin on spontaneous motor activity of rats
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 51 (1) , 81-84
- https://doi.org/10.1007/bf00426326
Abstract
Spontaneous motor activity was studied following injection of 1, 10 and 50 μg of serotonin (5-HT) into the lateral ventricle of chronically cannulated rats. During the first 15 min, the rats receiving the higher doses of 5-HT showed significant decrements (P<0.01) in motor activity compared to saline controls. No activation was observed in either group. After 20 min, no significant differences for any treatment condition compared to saline controls were observed. It is concluded that a principal effect of directly increasing brain 5-HT concentration is to decrease activity. Possible mechanisms for this effect are discussed.This publication has 22 references indexed in Scilit:
- dl-5-Hydroxytryptophan-induced changes in central monoamine neurons after peripheral decarboxylase inhibitionJournal of Pharmacy and Pharmacology, 1971
- EFFECTS OF L-TRYPTOPHAN (A NATURAL SEDATIVE) ON HUMAN SLEEPThe Lancet, 1970
- Serotonin-Containing Neurons in Brain: Depression of Firing by Monoamine Oxidase InhibitorsScience, 1970
- Biogenic Amines and the States of SleepScience, 1969
- The effect of para-chlorophenylalanine on the sleep of catsElectroencephalography and Clinical Neurophysiology, 1968
- Feeding and temperature responses in the unrestrained rat after injections of cholinergic and aminergic substances into the cerebral ventriclesPhysiology & Behavior, 1968
- Excitatory effects of 5-HTP on intracranial self-stimulation following Mao blockadeLife Sciences, 1968
- Replenishment by 5-hydroxytryptophan of the amine stores in the central 5-hydroxytryptamine neurons after depletion induced by reserpine or by an inhibitor of monoamine synthesisJournal of Pharmacy and Pharmacology, 1967
- Cellular localization of monoamines in the area postrema of certain mammalsJournal of Comparative Neurology, 1965
- 5‐HYDROXYINDOLE METABOLISM IN RAT BRAIN. A STUDY OF INTERMEDIATE METABOLISM USING THE TECHNIQUE OF TRYPTOPHAN LOADING–I METHODSJournal of Neurochemistry, 1965