Lipopolysaccharidefrom the Periodontal PathogenPorphyromonas gingivalisPrevents Apoptosis of HL60-Derived Neutrophils InVitro
Open Access
- 1 December 2003
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 71 (12) , 7232-7235
- https://doi.org/10.1128/iai.71.12.7232-7235.2003
Abstract
Lipopolysaccharide (LPS) fromPorphyromonas gingivalisprevented apoptosis of HL60-derived neutrophils, which could not be restored upon the addition of interleukin-10. Signaling ofP. gingivalisLPS through Toll-like receptor 2 (TLR2), not TLR4, may account for the inhibiting effect ofP. gingivalisLPS on apoptosis and provide a mechanism for the development of destructive periodontal inflammation.Keywords
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