A Positron Emission Tomographic Study in Spontaneous Migraine

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Abstract
Migraine is an episodic brain disorder that results in significant morbidity1 for between 10% and 15% of the general population.2,3 Neuroimaging studies have contributed significantly to the understanding of primary headaches, such as migraine and cluster headache.4 These studies provide an opportunity to observe brain areas or networks that are likely to be involved in both the genesis and mediation of the syndromes. Because migraine is an episodic condition and neuroimaging requires considerable planning, spontaneous acute attacks have been difficult to study.