Interaction of cinnamaldehyde (a sensitizer in fragrance) with protein

Publisher Website
Google Scholar
Abstract
Formation of a cinnamaldehyde-protein conjugate in the skin by reaction of cinnamaldehye with nucleophilic groups in proteins is considered to be responsible for the observed immunogenicity. The kinetics of the reaction of bovine serum albumin with cinnamaldehyde in aqueous solution at 30.degree. C have been investigated, and the rate of formation of conjugate over the pH range 6.4-10.5 showed a first-order dependence on cinnamaldehyde concentration. The cinnamaldehyde binding sites on the protein appeared mostly or exclusively to be the thiol groups of cysteine residues.