ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth
- 15 May 2006
- journal article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 20 (10) , 1262-1267
- https://doi.org/10.1101/gad.374006
Abstract
ASPP2 stimulates the apoptotic function of the p53 family in vivo. We show here that ASPP2−/− pups died before weaning. This postnatal lethality was significantly enhanced in p53+/− background and both deletions are synthetic lethal. ASPP2+/− mice developed spontaneous tumors. The tumor onset was accelerated by γ-irradiation or in p53+/− background. Tumors derived from ASPP2+/− mice retained wild-type ASPP2 allele even though some of them lost p53. These provide the first genetic evidence that ASPP2 is a haploinsufficient tumor suppressor that shares overlapping function(s) with p53 in mouse development and tumor suppression.Keywords
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