DYNAMICS OF RED-CELL CHIMAERISM IN HISTOINCOMPATIBLE PARABIOSED MICE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 7  (8) , 425-434
Abstract
A new technique for quantitation of isoenzymes was applied to assess proportions of red cells in circulation of parabiosed mice. Two parent-F1 hybrid combinations showing phosphoglucose isomerase polymorphism were examined at successive stages of parabiosis and after separation. Once red cell populations became mixed, 3 days after union, the ratio of red cell phenotypes was never significantly different from 1 partner to the other, although parental red cells became predominant after about 20 days. F1 hybrid red cells could always be detected. After separation of parabiosed mice there was a return to original composition although this took longer than would be expected on the basis of reported red cell life span. Packed cell volume measurements indicated that parental polycythemia and F1 hybrid anemia developed in 1 strain combination but not in the other. Evidence was adduced to support the hypothesis of difference in red cell flux being responsible for generation of this polycythemia-anemia.

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