Hemolytic Disease and Polycythemia in Parabiosis Intoxication

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Abstract
Disharmoniouns parabiotic rats were studied, which had clinical, hematologic, pathologic and serologic evidences of blood incompatibility, isohemagglutinin hypersensitization and hemolytic anemia. Spherocytosis and increased incomplete isohemagglutinin antibodies, demonstrated by indirect Coombs-type agglutinations and with trypsinized rat erythrocytes, were found in both parabionts. One partner became anemic with reticulocytosis, erythroblastosis, bone marrow necrobiosis, reactive hematopoietic hyperplasia and enhanced extramedullary hematopoiesis. The other parabiont showed lymphoid and reticulo-endothelial hyperplasia, leukocytoid lymphocytosis and erythrophagocytosis. It was plethoric with polycythemia, increased blood volume and high blood pressure. The polycythemia was explained by mechanical trapping of sludged antibody-coated incompatible erythrocytes, which the reticulo-endothelial system was inadequate to process. Complicating hemoglobinemia and hemoglobinuric nephrosis developed. Other manifestations of parabiosis intoxication are briefly discussed.