PITUITARY-ADRENAL FUNCTION DURING PSEUDOPREGNANCY AND EARLY PREGNANCY IN RATS1

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Abstract
Adrenal weight is normal on the 12th day of pregnancy but reduced significantly on the 12th day of pseudopregnancy in rats. Adrenal ascorbic acid concentrations are normal in both pregnancy and pseudo-pregnancy on the 12th day. Removal of the left adrenal gland on the 2d day of either pregnancy or pseudopregnancy induces hypertrophy of the right adrenal (measured on the 12th day) of the same magnitude as in non-mated control rats. Results indicate a lower ACTH output in pseudopregnancy than in pregnancy. They also suggest that the secretion of gonadotropins during pregnancy or pseudopregnancy does not alter the ability of the pituitary to secrete ACTH in response to unilateral adrenalectomy.

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