Antigenic similarity of toxins produced by Clostridium botulinum type C and D strains

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Abstract
Antisera against purified type C1 toxin of C. botulinum and its H-chain component cross-neutralized type D toxin. Antisera against partially purified type D toxin cross-neutralized type C1 toxin. From the latter serum, a component which neutralized only type D toxin and a component which equally neutralized both type C1 and D toxins were obtained. The cross-neutralization was not due to the fact that type C and D strains produce both C1 and D toxins but rather to the fact that the toxins have an antigen(s) common to their molecules. The results of the agar gel-double-diffusion test also supported this conclusion.