Depletion of Erythrocyte Phosphoribosylpyrophosphate in Man
- 26 November 1970
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 283 (22) , 1177-1182
- https://doi.org/10.1056/nejm197011262832201
Abstract
Allopurinol, a potent inhibitor of xanthine oxidase, is widely used for the treatment of hyperuricemia. When this drug was given to nine patients with gout, the concentration of phosphoribosylpyrophosphate (PRPP) in red cells was reduced significantly (p<0.01). Studies in vivo and in vitro showed that this depletion of PRPP results from the enzymatic conversion of allopurinol to allopurinol ribonucleotide, a process that consumes PRPP.Keywords
This publication has 16 references indexed in Scilit:
- Regulation of purine biosynthesis in cultured human cells: I. Effects of orotic acidBiochimica et Biophysica Acta (BBA) - General Subjects, 1970
- Allopurinol: Alteration in Pyrimidine Metabolism in ManScience, 1970
- Orotidinuria Induced by AllopurinolScience, 1970
- Effects of allopurinol and oxipurinol on purine synthesis in cultured human cellsJournal of Clinical Investigation, 1970
- Regulation of the synthesis of 5-phosphoribosyl-i-pyrophosphate in intact red blood cells and in cell-free preparationsBiochimica et Biophysica Acta (BBA) - General Subjects, 1969
- The Control of Nucleotide BiosynthesisAnnual Review of Biochemistry, 1968
- Inherited disorder of purine metabolism. Correlation between central nervous system dysfunction and biochemical defectsPublished by American Medical Association (AMA) ,1967
- The distribution of serum uric acid values in a population unselected as to gout or hyperuricemiaThe American Journal of Medicine, 1965
- Effect of allopurinol (4-Hydroxypyrazolo-(3,4-d)pyrimidine) on serum and urinary uric acid in primary and secondary goutThe American Journal of Medicine, 1964
- URIC ACID PRODUCTION IN GOUTJournal of Clinical Investigation, 1961