THE INHIBITION OF YEAST CARBOXYLASE BY HOMOLOGOUS ANTISERUM

Abstract
Antiserum prepd. against purified carboxylase, dried yeast cells, and living whole yeast cells inhibited the activity of the isolated carboxylase. None of these immune sera had any effect on the carboxylase activity of the dried yeast cells or the cresyl violet-treated whole yeast cells. Yeast carboxylase and hexokinase appear to be ihtracellular. The homologous antibodies of these enzymes, because of their large molecular size, seem incapable of penetrating the cell walls for a reaction with these intracellular enzymes.

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