Protective effects of antioxidants against endrin-induced lipid peroxidation, glutathione depletion, and lethality in rats

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Abstract
Endrin depletes glutathione levels and induces lipid peroxidation in various species of animals. We have, therefore, examined the effect of antioxidants on these parameters in endrin-treated rats. Butylated hydroxyanisole (BHA), vitamin E, vitamin C, and the glutathione precursor cysteine significantly inhibited hepatic glutathione depletion and lipid peroxidation induced by 4 mg endrin/kg body weight. Furthermore, these antioxidants provided partial protection against lethality produced by 8 mg endrin/kg body weight. These results suggest but do not prove that free radical-mediated lipid peroxidation and glutathione depletion may be involved in the toxic manifestations of endrin.