Mechanism of the Cortisone-Modified Glucose Tolerance Test

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Abstract
BY use of a cortisone-modified glucose tolerance test Fajans and Conn12 found marked susceptibility to the diabetogenic effect of cortisone far more frequently among nondiabetic relatives of diabetic patients than among subjects with no known family history for diabetes. The mechanism of this cortisone effect has not been established. Long and his co-workers3 demonstrated in 1940 that the partially depancreatized rat was more susceptible to the diabetogenic effect of adrenocortical extracts than intact animals, and nine years later Zucker4 reported similar findings in rabbits given subdiabetogenic amounts of alloxan. These observations, interpreted in conjunction with morphologic evidence of increased islet . . .