ADENOID CYSTIC CARCINOMA - A 3RD TYPE OF HUMAN SALIVARY-GLAND NEOPLASM CHARACTERIZED CYTOGENETICALLY BY RECIPROCAL TRANSLOCATIONS

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 2  (1-2) , 11-15
Abstract
Using G-banding technique, the chromosomes were studied in 4 consecutive preparations from cultured material from a human adenoid cystic carcinoma of the submandibular gland. The carcinoma had originated with a normal diploid stemline, and that reciprocal translocations played a predominant role in the development of an abnormal stemline. The propensity of developing variant cells, as well as an abnormal stemline, characterized by various types of reciprocal translocations, was a property shared by 2 other types of salivary gland neoplasms studied by banding techniques, namely the pleomorphic adenoma and the acinic cell tumor. The tissue of origin is suggested to be the crucial determinant responsible for this important cytogenetical similarity between different types of salivary gland tumors.