INFECTIONS OF BRUGIA-PAHANGI IN CONVENTIONAL AND NUDE (ATHYMIC) MICE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 37  (4) , 327-335
Abstract
AKR, BALB/c and CBA/Ca and T.O. mice were completely resistant to infection with 3rd stage infective larvae of B. pahangi. Third, 4th and 5th stage worms transplanted from the peritoneal cavity of jirds into the peritoneal cavity of mice continued to develop. BALB/c mice were the most susceptible of the strains tested and adult worms were obtained after each type of transplanted infection. Congenitally athymic nude mice were much less resistant to transplanted worms and infective larvae developed to full maturity in most of them. Ten of 14 athymic mice infected by the i.p. inoculation of infective larvae had microfilariae in their blood or peritoneal cavities. At autopsy, a percentage recovery of adult worms of 0-38% (mean 11.1%) was obtained. Microfilariae were only found in the blood of 2 of 6 athymic mice infected by s.c. injection and at autopsy 0-19.1% (mean 6.1%) recoveries were obtained. The thymic littermates of the nudes were more resistant than those of most of the other strains used.

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