Tissue factor expression correlates with histological grade in human pancreatic cancer
- 1 August 1995
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Surgery
- Vol. 82 (8) , 1101-1104
- https://doi.org/10.1002/bjs.1800820831
Abstract
The transmembrane cellular receptor tissue factor (TF) is the primary initiator of the coagulation cascade in man. Expression of TF was determined in 55 specimens of ductal adenocarcinoma of the pancreas and was found to correlate strongly with the degree of histological differentiation. A significant linear trend was observed with stronger immunoreactivity observed in poorly differentiated tumours (X2 = 6·69, P = 0·0098). No TF staining was seen in pancreatic samples from normal controls (n = 18). As expression of TF may be associated with tumour progression, its analysis could provide useful prognostic information in patients with pancreatic malignancy.Keywords
Funding Information
- The special trustees of the Hammersmith and Queen Charlotte's Special Health Authority
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