Effects of Gonadotrophic Hormones on Lactation.

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Abstract
The effects of a crude ant. pituitary powder (40 mg./day), chorionic gonadotrophin (150-450 I.U./day) and pregnant mare serum (300 and 600 I.U./day) were studied in lactating rats. Injns. were started within 24-36 hrs. of parturition and continued during 16 days. The criteria were provided by the growth curve and the percentage of deaths among the young. PMS was the most active inhibitor of lactation resulting in the death of most of the young; APL had only a slight effect on the growth curve, while the ant. pituitary prepn. was inactive. From histologic studies of the ovary, vagina, and uterus, it is suggested that the activity of PMS is due to the formation of large corpora lutea secreting a high level of estrogens and progesterone.

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