EFFECTS OF OPHTHALMIC VEHICLES ON THE STABILITY OF THE PRECORNEAL FILM

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Abstract
The break up time (BUT) of the precorneal film was studied before and after application of 34 different vehicles. The material examined comprised 646 [human] eyes. Maximum increase of the BUT was obtained with 2% methyl cellulose (4 times) and 10% polyvinyl alcohol (7 times). These vehicles in the usually empolyed concentrations, fat-free ointment (polyethylene glycol), acetylcysteine and polysaccharide (dextran) affected a less pronounced prolongation. The BUT was reduced 4 or 5 times by fatty, anhydrous ointments and by silicone oil, about 2 or 3 times by emulsions and oils and twice by 0.01% benzalkonium chloride. The clinical significance of the BUT alterations was discussed.

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