Glycoprotein Biosynthesis in Human Reticulocytes: A Lesion in Thalassemia
- 19 February 1965
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 147 (3660) , 869-870
- https://doi.org/10.1126/science.147.3660.869
Abstract
The rate of incorporation of glucosamine into the glycoprotein of reticulocyte stroma is greatly increased in thalassemia. This increase suggests a major enzymic disorder in the buildup of cellular membrane and reconciles the accumulation of material showing a positive reaction with periodic acid Schiff reagent with the clinical picture of oligocythemia and microcytosis.Keywords
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