SARS-Associated Coronavirus Quasispecies in Individual Patients
Open Access
- 25 March 2004
- journal article
- letter
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 350 (13) , 1366-1367
- https://doi.org/10.1056/nejmc032421
Abstract
Quasispecies are known in RNA viruses such as hepatitis C virus and human immunodeficiency virus.1 Owing to poor fidelity of RNA polymerases, RNA-virus populations typically contain genetic variants that form a heterogeneous virus pool. The severe acute respiratory syndrome (SARS)–associated coronavirus, as a newly identified RNA virus,2 however, has been reported with relatively limited variations,3,4 and no published data have recorded the existence of quasispecies.Keywords
This publication has 4 references indexed in Scilit:
- Coronavirus Genomic-Sequence Variations and the Epidemiology of the Severe Acute Respiratory SyndromeNew England Journal of Medicine, 2003
- Identification of a Novel Coronavirus in Patients with Severe Acute Respiratory SyndromeNew England Journal of Medicine, 2003
- Comparative full-length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infectionThe Lancet, 2003
- Quasispecies and the development of new antiviral strategiesPublished by Springer Nature ,2003