THE EFFECTS OF ATROPINE AND OXOTREMORINE ON ACETYLCHOLINE RELEASE IN RAT PHRENIC NERVE‐DIAPHRAGM PREPARATIONS

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Abstract
1 Atropine (10−5m) enhanced the release of [3H]-acetylcholine from rat isolated hemidiaphragms, previously incubated with [3H-methyl]-choline, stimulated via their phrenic nerves. 2 Oxotremorine (10−5m) did not affect the stimulated release of [3H]-acetylcholine but antagonized the facilitatory effects of atropine (10−5m). 3 It is suggested that there are presynaptic inhibitory muscarinic receptors that modulate the release of acetylcholine in the phrenic nerves of the rat.