Retinal pigment epithelium contains a distinctive strychnine-binding site
Open Access
- 1 December 1982
- journal article
- research article
- Published by Springer Nature in Neurochemical Research
- Vol. 7 (12) , 1445-1452
- https://doi.org/10.1007/bf00965087
Abstract
Membranes prepared from the retinal pigment epithelium of several species possess a specific site which binds [3H]strychnine. This binding has a somewhat lower affinity and a much greater density than the corresponding interaction in the hindbrain or neural retina. Binding is not greatly altered in the presence of 10−3 M glycine,l-alanine, β-alanine, taurine, or serine. Thus, the receptor does not resemble the classical glycine receptor of the hindbrain and spinal cord. This new type of binding site appears to be confined to the pigment epithelial layer of the retina.This publication has 34 references indexed in Scilit:
- Identification of Strychnine Binding Sites in the Rat RetinaJournal of Neurochemistry, 1981
- Light-induced calcium fluxes from outer segment layer of vertebrate retinasNature, 1980
- Interaction of drugs with ocular melanin in vitroExperimental Eye Research, 1980
- Electrophysiological responses related to the pigment epithelium and its interaction with the receptor layerNeurochemistry International, 1980
- Localization of receptors for kainic acid on neurons in the innernuclear layer of retinaNeuropharmacology, 1979
- GLYCINE SPECIFIC [3H]STRYCHNINE BINDING IN THE PIGEON CNSJournal of Neurochemistry, 1978
- Benzodiazepine activity: is interaction with the glycine receptor, as evidenced by displacement of strychnine binding, a useful criterion?Journal of Pharmacy and Pharmacology, 1977
- Glycine, strychnine and retinal inhibitionCellular and Molecular Life Sciences, 1974
- Light-evoked release of glycine from the retinaNature, 1974
- THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONSAnnals of the New York Academy of Sciences, 1949