Muscular Involvement in Rheumatoid Arthritis

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Abstract
Summary Groups of selected patients with rheumatoid arthritis and symptoms of muscular involvement were studied. Muscle biopsies showed foci of lymphocytes and degradation of contractile elements in a large proportion of the cases. Serum enzyme activity (CPK, GOT, LDH) was essentially normal in the patients studied. Only serum aldolase was frequently elevated. This was probably of non-muscular origin. Serum creatine was higher in the rheumatic patients than in normal subjects while serum creatinine was lower than in normal subjects. The creatine-creatinine ratio was higher in the rheumatic group of patients than in control subjects. The differences were statistically highly significant.

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