Effects of pregnancy on glucose handling by rat kidneys.

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Abstract
Glomerular filtration rate (g.f.r.), and renal reabsorption and excretion of glucose, Na and K were measured in 7-8 day pregnant rats and age matched (12-13 wk old) virgin controls undergoing saline and glucose infusions. Pregnancy was associated with an increased g.f.r. and a decreased urine flow rate during both infusions. During saline infusion, more glucose was excreted in pregnant animals than in virgins, but with no significant difference in fractional reabsorption. During glucose infusion, pregnant animals excreted less glucose than virgins, owing to a decrease in the filteraed load, but with no significant difference in fractional reabsorption. During both saline and glucose infusion, pregnant animals excreted less Na than virgin controls. During saline infusion, pregnant animals excreted more K. During glucose infusion, pregnant animals excreted less K than control animals.