Synthetische Tripeptide als Chemotaxine bzw. Chemotaxinantagonisten

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Abstract
The possibility of changing N-terminally protected tripeptides with chemotactic activity into antagonists by variation of the protecting group was investigated. Chemotactic activity in the agarose test was shown for a series of new structurally related formylated tripeptides. The effect could be antagonized with 1 exception by Boc[tert-butoxycarbonyl] analogs. These antagonists are very likely bound to the same membrane receptor of [human] polymorphonuclear leukocytes as the chemotaxins. The antagonists do not influence the activity of the naturally occurring chemotaxin C5a [fragment a of complement component 5]. The syntheses of the test compounds are described.