Pharmacokinetics of E -5-(2-Bromovinyl)-2′-Deoxyuridine in Mice

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Abstract
The pharmacokinetics of the newly developed anti-herpes agent, E -5-(2-bromovinyl)-2′-deoxyuridine, was compared with that of the standard anti-herpes drug 5-iodo-2′-deoxyuridine. Both compounds were administered to mice at 100 mg/kg by either the intraperitoneal, subcutaneous, or oral route. The active blood drug levels achieved by E -5-(2-bromovinyl)-2′-deoxyuridine were considerably higher than those attained by 5-iodo-2′-deoxyuridine (serum peak concentrations: 40 to 100 and 4 to 10 μg/ml, respectively). Active blood drug levels could still be found 320 min after oral administration of E -5-(2-bromovinyl)-2′-deoxyuridine.