Follicular development in the neonatal mouse ovary; effect of epidermal growth factor
- 1 January 1981
- journal article
- research article
- Published by Bioscientifica in Acta Endocrinologica
- Vol. 96 (1) , 123-126
- https://doi.org/10.1530/acta.0.0960123
Abstract
Newborn females injected daily with EGF for the first 5 days of life showed ovarian development retardation. The number of follicles in the resting pool (small follicles) was significantly greater than in control animals and there were fewer growing follicles at more advanced stages of development (types 3b and 4). The percentage of mitotic figures in the follicular and surface epithelia of the ovary and the epithelium of the extra-ovarian rete was also significantly reduced after EGF. EGF may inhibit rather than promote the growth of follicles in the neonatal mouse ovary in vivo.This publication has 11 references indexed in Scilit:
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