Cimetropium Bromide: In vitro and in vivo Evaluation of Spasmolytic Activity on Human and Dog Colon

Publisher Website
Google Scholar
Abstract
The present study investigates the spasmolytic properties cimetropium bromide, compared to atropine, on human and canine large bowel. The drug behaved as a competitive antagonist of muscarinic-mediated contractions in isolated colonic preparations from both species, with affinity values (pA2) ranging between 7.41 and 7.82. When administered intravenously to conscious dogs provided with a colonic Thiry fistula, cimetropium was a potent inhibitor of large bowel motility evoked by both exogenous and endogenous stimuli. The compound (10-100 .mu.g/kg) counteracted colonic motor response to neostigmine administration with an ID50 of 27.9 .mu.g/kg; both tonic and phasic components of contractile response were affected. In a comparable range of doses (3-100 .mu.g/kg), the drug inhibited motor activity elicited by intraluminal distension.