Prenatal diagnosis of triploidy

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Abstract
Two patients with late midtrimester triploid gestation are presented. The unusual condition might be suspected in cases of 1st and 2nd trimester bleeding when the uterus appears to be unusually large as estimated by the menstrual history. Early presence of gestational hypertension also points suggestively toward a triploid fetus. Ultrasound examination of the placenta typically shows multiple sonolucent areas. Confirmation of diagnosis is made by karyotyping cells obtained from amniotic fluid. The condition is incompatible with life and termination of pregnancy is indicated. HCG [human chorionic gonadotropin] levels should be followed for evidence of persistent trophoblastic tissue.
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