Different cell clones in bone marrow and spleen of a patient with chronic myelocytic leukemia (CML) in blastic phase
- 1 December 1978
- Vol. 42 (6) , 2707-2709
- https://doi.org/10.1002/1097-0142(197812)42:6<2707::aid-cncr2820420627>3.0.co;2-5
Abstract
The chromosome study of a patient with chronic myelocytic leukemia in blastic phase revealed a 46,XY,Ph1/47,XY,Ph1,+8 cytogenetic constitution in bone marrow cells and a 46,XY,Ph1/48,XY,2Ph1, + 19 cytogenetic constitution in spleen cells. As the cell clones exhibiting chromosome abnormalities in addition to the Ph1 chromosome evolved apparently independently, it is suggested that the acute transformation had a bifocal, myeloid and splenic origin. Cancer 42:2707–2709, 1978.This publication has 16 references indexed in Scilit:
- Cytogenetic Evidence for Splenic Origin of Blastic Transformation in Chronic Myeloid LeukaemiaScandinavian Journal of Haematology, 2009
- Non‐random karyotypic evolution in chronic myeloid leukemiaInternational Journal of Cancer, 1976
- Chromosomes and causation of human cancer and leukemiaXVI. Banding studies of chronic myelocytic leukemia, including five unusual Ph1translocationsCancer, 1975
- Removal of abnormal clone of leukaemic cells by splenectomy.BMJ, 1975
- Extramedullary manifestation of the blastic phase of chronic myelocytic leukemia: A chromosome studyZeitschrift für Krebsforschung und Klinische Onkologie, 1975
- Additional chromosomal indication for the unicellular origin of chronic myelocytic leukemiaZeitschrift für Krebsforschung und Klinische Onkologie, 1975
- On the Monoclonal Origin of Chronic Myelocytic LeukemiaProceedings of the Japan Academy, 1974
- A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa StainingNature, 1973
- Monoclonal Origin of Acute Transformation of Chronic Myelogenous LeukemiaActa Haematologica, 1973
- Clonal Origin of the Philadelphia Chromosome and Chronic Myeloid Leukaemia: Evidence from a Sex Chromosome MosaicBritish Journal of Haematology, 1971