Selective Brain Dopamine Depletion in Developing Rats: An Experimental Model of Minimal Brain Dysfunction
- 23 January 1976
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 191 (4224) , 305-308
- https://doi.org/10.1126/science.942800
Abstract
Administration of 6-hydroxydopamine to neonatal rats produces a rapid and profound depletion of brain dopamine. Total activity of treated animals is significantly greater than that of controls between 12 and 22 days of age, but then declines, an activity pattern similar to that seen in affected children. This suggests a functional deficiency of brain dopamine in the pathogenesis of minimal brain dysfunction.Keywords
This publication has 22 references indexed in Scilit:
- Dopamine Receptors in the BrainScience, 1975
- Some speculations concerning a possible biochemical basis of minimal brain dysfunctionLife Sciences, 1974
- Effects of intracisternal 6-hydroxydopamine treatment on acquisition and performance of rats in a double T-maze.Journal of Comparative and Physiological Psychology, 1974
- Exploratory activity and conditioned avoidance acquisition after early postnatal 6-Hydroxydopamine administrationJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1973
- Sex differences in rats’ stationary-cage activity measured by observation and automatic recordingLearning & Behavior, 1973
- HOW AMPHETAMINE ACTS IN MINIMAL BRAIN DYSFUNCTION *Annals of the New York Academy of Sciences, 1973
- TYROSINE HYDROXYLASE IN RAT BRAIN: DEVELOPMENTAL CHARACTERISTICSJournal of Neurochemistry, 1972
- DOPAMINE‐β‐HYDROXYLASE IN THE RAT BRAIN: DEVELOPMENTAL CHARACTERISTICSJournal of Neurochemistry, 1972
- Ontogeny of behavioral arousal: A comparative study.Journal of Comparative and Physiological Psychology, 1972
- Ontogeny of Adrenergic Arousal and Cholinergic Inhibitory Mechanisms in the RatScience, 1969