Effect of Hyperuricemia on Renal Function in the Dog

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Abstract
Summary Renal function in dogs, as assessed by the clearances of creatinine and para-aminohippurate, was impaired by hyperuricemia induced by intravenous injections of uric acid. The degree of functional impairment was related to dosage and to frequency of injection and was possibly aggravated by the presence of renal disease. It was more severe in mongrel than in Dalmatian dogs. Small doses, which singly produced no detectable functional impairment, caused renal damage after repeated daily injections, indicating a cumulative effect. The findings suggest that hyperuricemia may produce significant nephropathy by urate blockage of the distal convoluted and collecting tubules. Such hyperuricemic nephropathy, reversible up to a certain point, may become chronic or fatal if permitted to continue unchecked.