Induced Fibrinolytic Activity and Hypofibrinogenemia

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Abstract
The introduction of therapeutic preparations that produce a fibrinolytic state has created a need for a neutralizing agent or inhibitor that can be used in any emergency in the event of hemorrhage resulting from over-dosage of the drugs or hypersensitivity to them. In 1953, De Vries6 demonstrated the activity of amino acids as inhibitors of fibrinolytic activity. In 1959 Okamoto and his co-workers15 published an account of their earlier discovery of ε-amino-caproic acid (EACA) as a potent inhibitor of fibrinolysis. They named the product Ipsilon.5,21 Sarker,19 Sjoerdsma,20 Ablondi,2 and Alkjaersig3 substantiated these findings. The mechanism of inhibition of lysis by ε-amino-caproic acid has been shown to be one of preventing the activation of plasminogen rather than the neutralization of fibrinolytic activity of plasmin.1-3,10,8 The creation of a bleeding state in dogs by the use of plasmin or an activator, and its subsequent