Antihypertensive Function of a Renal-Cell Carcinoma

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Abstract
THE secretion of biologically active hormone-like materials by neoplastic cells is a well recognized phenomenon. Tumor extracts have been shown to possess biological activity compatible with adrenocorticotropin, melanocyte-stimulating hormone, thyroid-stimulating hormone, antidiuretic hormone, parathyroid hormone, insulin, glucagon, gastrin, serotonin and erythropoietin.1 Renal-cell carcinomas, in particular, have been associated with the secretion of erythropoietin,2 renin3 and parathyroid hormone.4 , 5 In the case recorded below, elevated plasma prostaglandin A concentrations were associated with a renal-cell carcinoma.Case ReportA 49-year-old woman (N.E.M.C.H. 81–22–77) was admitted to the hospital for evaluation of fatigue, anemia, anorexia and a weight loss of 9.1 kg. Twenty years . . .