An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs.
Open Access
- 1 March 1990
- journal article
- research article
- Published by Springer Nature in The EMBO Journal
- Vol. 9 (3) , 857-868
- https://doi.org/10.1002/j.1460-2075.1990.tb08183.x
Abstract
We previously identified a putative T cell oncogene on chromosome 11 near a translocation t(11;14)(p15;q11) in a human T cell tumour. The gene is transcribed from distinct promoters which have unrelated sequences, which occur within close but distinct methylation‐free islands and which allow cell specific production of mRNA. The alternative first exons each contain a protein initiation codon from which two species of protein can be made, differing by only a single amino acid. The protein sequence is highly conserved between man and mouse (98%) and the same single codon difference between alternative first exons is also conserved. This is, therefore, a new form of eukaryotic gene organization from which similar proteins can be made from distinct mRNA species.This publication has 25 references indexed in Scilit:
- The “initiator” as a transcription control elementCell, 1989
- Chromosomal translocation in T-cell leukemia line HUT 78 results in a MYC fusion transcript.Proceedings of the National Academy of Sciences, 1988
- Chromosomal abnormalities in lymphoid tumours: mechanism and role in tumour pathogenesisTrends in Genetics, 1988
- Immunoglobulin VH genes are transcribed by T cells in association with a new 5' exon.The Journal of Experimental Medicine, 1988
- Generation of Protein Isoform Diversity by Alternative Splicing: Mechanistic and Biological ImplicationsAnnual Review of Cell Biology, 1987
- Gene encoding the alpha chain of the T-cell receptor is moved immediately downstream of c-myc in a chromosomal 8;14 translocation in a cell line from a human T-cell leukemia.Proceedings of the National Academy of Sciences, 1986
- Diversity and rearrangement of the human T cell rearranging γ genes: Nine germ-line variable genes belonging to two subgroupsCell, 1986
- Alternative transcription and two modes of splicing result in two myosin light chains from one geneNature, 1984
- Translocation joins c-myc and immunoglobulin γ1 genes in a Burkitt lymphoma revealing a third exon in the c-myc oncogeneNature, 1983
- A single mouse α-amylase gene specifies two different tissue-specific mRNAsCell, 1981