Translocation joins c-myc and immunoglobulin γ1 genes in a Burkitt lymphoma revealing a third exon in the c-myc oncogene
- 1 July 1983
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 304 (5922) , 135-139
- https://doi.org/10.1038/304135a0
Abstract
Recombinant DNA clones were used to directly demonstrate that the Burkitt lymphoma cell line Raji, t(8;14) (q24;q32), has a rearranged copy of the c-myc gene adjacent to the .gamma.1 constant region gene of the human Ig H-chain locus; the genes are arranged in the opposite direction for transcription. At least one further 5'' exon was detected in the normal c-myc gene by analysis of RNA transcripts, and the occurrence of high levels of 2 c-myc mRNA size classes, both apparently initiating in this exon, is described.Keywords
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