TheSry-related HMG box-containing geneSox6is expressed in the adult testis and developing nervous system of the mouse
- 1 January 1995
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 23 (17) , 3365-3372
- https://doi.org/10.1093/nar/23.17.3365
Abstract
We have cloned and sequenced a full-length cDNA for the HMG box-containing, SRY-related gene Sox6 from mouse. The deduced protein sequence of Sox6 has considerable homology with that of the previously determined Sox5 sequence. It seems likely that these genes have diverged more recently than other members of the SOX gene family, although the two genes map to different chromosomes in the mouse. In common with Sox5, Sox6 is highly expressed in the adult mouse testis and the HMG domains of both proteins bind to the sequence 5'-AACAAT-3'. This suggests that the two genes may have overlapping functions in the regulation of gene expression during spermatogenesis in the adult mouse. However, Sox6 may have an additional role in the mouse embryo, where it is specifically expressed in the developing nervous system.Keywords
This publication has 38 references indexed in Scilit:
- Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related geneNature, 1994
- TRANSCRIPTION FACTORS: Structural Families and Principles of DNA RecognitionAnnual Review of Biochemistry, 1992
- X-Ray Structure of the GCN4 Leucine Zipper, a Two-Stranded, Parallel Coiled CoilScience, 1991
- Male development of chromosomally female mice transgenic for SryNature, 1991
- Use of bacteriophage T7 lysozyme to improve an inducible T7 expression systemJournal of Molecular Biology, 1991
- A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motifNature, 1990
- Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrainNature, 1989
- How eukaryotic transcriptional activators workNature, 1988
- Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferaseGene, 1988
- A general method applicable to the search for similarities in the amino acid sequence of two proteinsJournal of Molecular Biology, 1970