Acid base status in unanesthetized, unrestrained guinea pigs
- 1 January 1980
- journal article
- research article
- Published by Springer Nature in Pflügers Archiv - European Journal of Physiology
- Vol. 384 (1) , 93-97
- https://doi.org/10.1007/bf00589520
Abstract
Acid-base status of arterial blood was measured in chronically cannulated, unanesthetized, unrestrained guinea pigs. Normal values were: pH=7.444±0.032,PaCO2=35.7±4.4; HCO 3 − =24.4±2.8; BE=+0.4±2.1 (n=69) andPaO2=91.9±7.3 (n=25) (Values are mean±S.D.). Induction of light anesthesia with thiopentone caused a respiratory depression (decrease inPaO2) accompanied by respiratory acidosis (increase inPaCO2 and decrease in pH) and a development of slight metabolic acidosis (decrease in base excess and standard bicarbonate). Acid base parameters of guinea pigs are compared to those obtained from rats under identical experimental conditions.Keywords
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