Suppression of Interferon Production by Vitamin A
Open Access
- 1 July 1976
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 32 (1) , 143-147
- https://doi.org/10.1099/0022-1317-32-1-143
Abstract
Vitamin A (retinoic acid) suppressed interferon production by L cells infected with Newcastle disease virus (NDV). This suppression was maximal when cells were treated with retinoic acid for 2 h after NDV adsorption, indicating that the inhibitory step was an early event. It was not due to inhibition of total RNA synthesis. Retinoic acid treatment caused both a delay in appearance of interferon and a reduced rate of synthesis thereafter.This publication has 5 references indexed in Scilit:
- The effect of trauma on production of herpes interferon in guinea pigsArchiv für die gesamte Virusforschung, 1967
- Interferon production in chick-embryo cells. The effect of puromycin and p-fluorophenylalanineBiochemical Journal, 1966
- Reversible inhibition of interferon synthesis by puromycin: evidence for an interferon-specific messenger RNA.Proceedings of the National Academy of Sciences, 1965
- Metabolic determinants of interferon formationVirology, 1965
- Messenger RNA for Interferon ProductionExperimental Biology and Medicine, 1965