The distribution of a potential Molluscicide,3H‐aridanin, in mice(Mus Musculus)and snails(Biomphalaria Glabrata)

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Abstract
The molluscicide Aridanin was labelled with 3H and its tissue distribution was studied in mice and snails (B. glabrata) by whole‐body autoradiography and liquid scintillation. In mice intravenously injected 3H‐Aridanin was rapidly taken up in the kidney and liver. Its elimination—mainly through the faeces and to a lesser extent through the urine—was rapid. About 40 % of the total Aridanin dose was excreted after 24 h. No specific retention in any tissue was observed after 24 h and Aridanin did not pass the placental barrier in pregnant mice. After oral administration to mice most of the labelled Aridanin was found in the intestinal contents indicating a very poor absorption. In the snails incubated in labelled Aridanin the radioactivity was extensively concentrated in comparison to the surrounding medium, and a retention was registered in many organs (kidneys, hepatopancreas, gastrointestinal tract) up to 72–96 h after incubation. A gradual increase in the ovotestes was observed during the experiment. Preliminary chromatographic studies indicate a difference in metabolism between the mice and snails. The study showed that the rapid uptake and disappearance and low oral uptake of Aridanin in a non‐target mammal (mice) and the accumulation and retention of Aridanin in target snails make this molluscicide a suitable substance to be tested in field studies.