Effects of Acute Decompression Stress Upon Plasma Electrolytes and Renal Function in Dogs

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Abstract
Effects of hypoxia, produced by decompression to a simulated altitude of 30,000 ft. for 90 min., were studied upon unanesthetized dogs. Special attention was given to changes in plasma electrolytes and renal function. Plasma K concn. consistently decreased (avg. 19%) during decompression; plasma Na concn. remained unchanged. Hematocrit values increased and the eosinophil count showed a downward trend which continued for 90 min. after decompression had been discontinued. In the kidney, glomerular filtration rate remained unchanged during decompression, but urine flow decreased markedly (avg. 43%), indicating increased tubular reabsorption of water. Effects upon Na excretion were variable, but K excretion consistently increased (avg. 35%). Since the latter effect occurred simultaneously with decreased K filtration, it indicates decreased tubular reabsorption and/or increased tubular secretion of K during decompression.